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Advanced anabolic steroid users may or may not also engage in anabolic steroid cycle protocols that might seem out of the ordinary to beginners or against common comprehension. A review of the literature has noted that both muscle protein synthesis (MPS), a measure of adaptive capacity, and muscle protein accretion (MPA; a measure of hyperaminoacidemia and cellular oxygen demand) are increased following anabolic steroids.3 This increase is not limited to the acute acute effects of steroid cycles, although it can be. As discussed, and also discussed further here,4,5 MPS rates have been shown to be markedly altered following prolonged high dose anabolic steroids use (i.e. more than 24 weeks). Such alterations have not been observed for MPA rates.2,6 As discussed,7,8,9 the adaptive capacity of muscle is affected by high dose anabolic steroids use, but is also reduced somewhat following long-term use.10 More interestingly, even in the presence of decreased acute acute and/or long-term anabolic testosterone administration in the presence of lower than desired MPA rates and/or reduced anabolic steroid cycle rates, increased levels of a marker of muscle growth (a muscle fibre specific protein called MGF) have been shown.10 A study by D'Agostino and colleagues examined MGF levels in skeletal muscle from subjects in the testosterone + testosterone + aldosterone group.10 They found a statistically significant increase in MGF following a 12 week testosterone regimen, which in itself is an intriguing finding. Furthermore, the authors reported a positive relationship, independent of testosterone, in the rate of muscle hypertrophy. This finding is perhaps best explained by the observation that skeletal muscle cells need time to mature and accumulate new fibres. This is the reason that the acute effects of anabolic steroids will normally be more pronounced following a high dose period, where the body takes time to adapt into an anabolic state as opposed to a rapid recovery after use of a high dose steroids cycle. This is also the reason high dose anabolic steroids can increase MPA rates, for in order for the anabolic steroid user to achieve maximal gains in hypertrophy, anabolism must be maintained for a longer period of time. MPA was also noted to be reduced more markedly following testosterone use, despite the fact that MPA rates remained largely unaffected from administration of higher doses of testosterone (which, again, is consistent with the observation that skeletal muscle requires time to mature and accumulate new fibres). There have been a number of studies of both acute and chronic anabolic steroids administration in humans Similar articles: